Which of the following withdrawal characteristics can result from the abrupt cessation or reduction of high-dose depressant usage?

Which of the following withdrawal characteristics can result from the abrupt cessation or reduction of high-dose depressant usage?
A . The withdrawal symptoms associated with depressants are more serious than those of any other drugs of abuse.
B . Convulsions can be experienced that are indistinguishable from those occurring in grand mal epilepsy.
C . Detoxification and treatment must be carried out under close medical supervision.
D . Both a and c.
E . All of the above.

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Answer: E