If the total body clearance of a drug is 200 mL/min in a normal healthy adult and the renal clearance is 10 mL/min then one may assume that:

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If the total body clearance of a drug is 200 mL/min in a normal healthy adult and the renal clearance is 10 mL/min then one may assume that:
A . the drug is extensively metabolized.
B . greater than normal drug accumulation would occur in patients with moderate renal failure.
C . entero-hepatic recycling is significant.
D . the drug is not bound to plasma proteins.
E . the drug is concentrated in adipose tissue.

Answer: A

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