Which of the following factors would be important in determining the concentration of drug that would be reached in the cerebrospinal fluid for treatment of meningitis?

Which of the following factors would be important in determining the concentration of drug that would be reached in the cerebrospinal fluid for treatment of meningitis?

I. Oil/water partition coefficient

II. Binding to plasma protein

III. pKa of the drug
A . I only
B . III only
C . I and II only
D . II and III only
E . I, II and III

View Answer

Answer: E